Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine pathology in premenopausal women and it is a complex syndrome affecting various systems. Numerous studies have been made about how the PCOS effects on bone metabolism, but currently there is no clear information. Wnt pathway plays important role in the regulation of bone metabolism. The sclerostin(Scl) and Dickkopf-1 (DKK1) inhibit this pathway and they has recently become a therapeutic target of osteo...

Introduction: The criteria defining the threshold size of adrenal incidentaloma (AI) are >1 cm diameter. However, data about AI ≤1 cm diameter is scant. The aim of this study is to evaluate function of adrenal masses ≤1 cm and to compare them with adrenal masses >1 cm as well as to understand the possible utility of determining salivary cortisol in diagnosis of SCS in patients with AI.Method: The study included 137 consecutive patient...

Introduction: Polycycstic ovary syndrome (PCOS) is an important disorder in women of reproductive age which is characterised with menstrual dysfunction, anovulation and hyperandrogenism. 5–10% of the female population affected by this syndrome. Nesfatin-1 is a new anorexigenic hormone which is expressed from several regions of hypothalamus and peripheral tissues. Nesfatin-1 is related with obesity, insulin resistance and appetite. We aimed to evaluated the nesfatin-1 leve...

Purpose: Acromegaly, an uncommon disease, is existed in the result of over production of growth hormone (GH). It is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, plays an essential role in the regulation of vascular tone, glucose metabolism and atherosclerosis. UII belonging to somatostatin superfamily activates somatostatin receptors as well. The aim of this study was to ascertain ...